Life-Long Health Begins
With Maternal Nutrition

Trimacare® is a multi-micronutrient supplement
(MMS) including iron, folate, calcium.
Scientifically formulated for each trimester of
pregnancy.

Trimacare maternal nutrition
Trimacare maternal nutrition
PATENTED FORMULATION
100% VEGETARIAN
ADVANCED INGREDIENTS

>50% of pregnant women walk
into clinics with depleted reserves of an
average of 7–8 micronutrients

Pregnancy in India begins from a position of nutritional deficit.

52.2%

Pregnant Women
are Anaemic

18%

Births in India
are Preterm

12%

Births in India are
Low Birth Weight

These figures are not driven by iron deficiency alone. Pregnant Indian women routinely present with simultaneous deficiencies of folate, vitamin B12, vitamin D, iodine, zinc, choline, and other essential micronutrients — a constellation termed hidden hunger.

An iron-folic acid regimen addresses two of those deficiencies. The remaining five or more go unaddressed. IFA is the foundation - but it was never designed for a deficiency landscape this broad

60% adverse pregnancy outcomes
linked to hidden hunger.

IFC covers 3. She needs 20+.

Folate Iron Vit B12 Choline DHA Iodine Vit D Calcium Zinc Mg Vit C Vit E Vit B2 Vit B5 Selenium Copper Vit K Biotin

Three Pillars of Lifelong Health

Three converging frameworks establish maternal nutrition as a primary determinant of long-term offspring health.

1. Developmental Origins of Health and Disease (DOHaD)

"The DOHaD framework, established through decades of cohort and mechanistic research, has reframed maternal nutrition from a peripartum concern to a public-health lever that shapes a generation. Indian cohort data, most notably from the Pune Maternal Nutrition Study, confirm DOHaD effects in South Asian populations and document the distinctive thin-fat phenotype of Indian neonates - low overall body weight with relatively high fat mass, predisposing to lifelong metabolic risk."

Foundation of Developmental Origins of Health & Disease (DOHaD)

1
Maternal
Nutrition

Micronutrient status
shapes the intrauterine
environment.

2
Epigenetic
Programming

DNA methylation &
heritable gene
regulation

3
Fetal
Development

Organ architecture,
CNS, metabolic
pathways, immunity

4
Lifelong
Health

NCD risk, cognitive
capacity, metabolic
resilience

2. Epigenetics

The first human evidence came from the Dutch Hunger Winter cohort, where periconceptional famine exposure was associated with persistent DNA methylation differences six decades later. In the Indian context, the Pune Maternal Nutrition Study demonstrated that the imbalance between maternal vitamin B12 and folate during pregnancy is associated with offspring insulin resistance - linking one-carbon metabolism directly to long-term metabolic phenotype. A systematic review specific to Indian populations recommends policy expansion beyond iron-folic acid alone, citing the consistent association of low maternal B12 with adverse birth outcomes.

One-Carbon Metabolism Pathway

Adequate nutrition

Folate + B12Adequate substrates
SAMMethyl donor generated
Normal
Methylation
Proper gene regulation
Healthy
Development
Optimal organ function

Deficient nutrition

Depleted
Folate/B12
Insufficient substrates
Low SAMCompromised methylation
HypomethylationAltered gene expression
Disease
Trajectory
Lifelong NCD risk

3. The intergenerational cycle of malnutrition

If that child is female, she enters her own pregnancy already deficient. Recent analyses of Indian populations explicitly trace the micronutrient pathway through this cycle - maternal anaemia and chronic micronutrient shortages are associated with the thin-fat phenotype in newborns, perpetuating the intergenerational transmission of metabolic risk. The Lancet Maternal and Child Nutrition Series has documented that the effects of under-nutrition span at least three generations. The clinical implication is that intervention in this generation is intervention in the next.

The Intergenerational cycle of malnutrition

Depleted Mother Anaemia, multiple deficiencies
Deficient Adolescent Girl Enters reproduction depleted
Break the cycle Rx Trimacare®
LBW / Compromised
Infant
Stunting, impaired cognition

Maternal nutrition is the single most modifiable factor influencing pregnancy outcomes & the lifelong health of the offspring.

IFA alone is insufficient

Iron–folic acid (IFA) supplementation has been the cornerstone of antenatal nutrition programs in India since 1973. However, despite over five decades of implementation, anaemia continues to affect more than 50% of pregnant women.

This persistent burden highlights a critical gap: IFA addresses only two micronutrients in a clinical setting where deficiencies often span 7 or more essential micronutrients. It’s time to move beyond a limited approach and embrace comprehensive, multi-micronutrient supplementation for better maternal and fetal outcome.

Comparison of adverse pregnancy outcomes:

India
Developed
Countries
13
8

PTD (%)

27
7

LBW (%)

30
7

IUGR (%)

19
4

PE (%)

13
5

GDM (%)

Yesterday

Today’s standard

IFA

Iron + Folic Acid

MMS

Multi-micronutrient Supplement

WHO 2020 ANC guidelines
ICMR 2024 dietary guidelines
UNICEF Standard for LMIC ANC

MMS improves pregnancy outcomes

Fetal benefits:

  • Reduced risk of preterm birth by 55%.
  • Decreased risk of low birth weight by 15%.
  • Improved body composition, growth, respiratory health, & cognitive outcomes.
  • Lower risk of non-communicable diseases in adulthood, such as diabetes and cardiovascular disorders.

Maternal benefits:

  • Reduced risk of pre-eclampsia by 45%.
  • Lower risk of gestational diabetes, osteoporosis, & thyroid dysfunction.
  • Reduced incidence of maternal anemia compared to iron & folate supplementation alone.
  • Enhanced energy levels, improved immunity, & faster postpartum recovery.

Antenatal multiple micronutrient supplements that include iron and folic acid are recommended in the context of rigorous research, in pregnant populations with documented micronutrient deficiencies.

– World Health Organization Antenatal Care guideline (2016, updated 2020)

Why guidelines are
moving beyond IFA alone

  • IFA fixes hemoglobin alone. Not outcomes.
  • Anemia is multifactorial. B12, folate, copper, zinc — not iron alone.
  • Multi-micronutrient deficiency is the norm in Indian pregnancy.
  • Placental function needs more than iron. Iodine, choline, DHA carry their own load.
  • Evidence favours MMS over IFA. Across birth weight, anemia, and neurodevelopment.

Trimacare® Patented Pregnancy Supplement

20+ Multi-micronutrient Supplement (MMS), including Iron, Folate & Calcium

Scientifically Formulated for each Trimester of Pregnancy

Trimacare patented pregnancy supplement
Fetal Brain &
Cognitive Development
Fetal Growth &
Organ Maturation
Maternal Health &
Postpartum Recovery

Scientifically formulated for each
trimester of pregnancy

Trimacare® 1

For Preconception,
IVF & 1st Trimester
30
Tablets
1 Tablets
per day
Trimacare 1

Reduces
Morning sickness

Ginger + B6 anti-emetic blend

Supports
Neural tube formation

5-MTHF + Choline methyl-donor support

Reduces
Pregnancy fatigue

B-complex + Iodine energy metabolism

4th Generation Bioactive Folate (6S)-5-MTHF): 570 mcg | Choline: 100 mg | Veg Omega 3 (EPA:DHA 2:3): 100 mg | Anti emetic botanical blend: 200 mcg | Iodine: 200 mcg | Vitamin D: 600 IU | Vit B12: 2.45 mcg

Replace Folic Acid with Trimacare® 1
for Superior Outcomes in IVF Therapy.

  • Improved embryo quality.
  • Higher success rates in first attempt to achieve pregnancy.
  • Better fertilization & clinical pregnancy outcomes.
MMN Folate
58
36

Pregnancy (%)
in first attempt

67
43

Fertilization
rate (%)

40
26

Pregnancy
rate (%)

Trimacare® 2

2nd Trimester 60
Tablets
BD
Trimacare 2

Reduces Anemia Risk

Iron + Vit C + Folate + Zinc + B12 for normal RBC formation

Reduces Brain Fog

Choline + DHA + Iodine Neurotransmission support

Support Bone & Muscle

B-complex + Calcium + Vit D + Magnesium + Iron Energy metabolism

Iron (ferrous fumarate): 27 mg | Vit C: 60 mg | Choline: 200 mg | Algal Omega 3 (EPA+DHA; 2:3): 200 mg | Vit B12: 2.45 mcg | Iodine: 200 mcg | Zinc: 12 mg | (6S)-5-MTHF: 570 mcg (Dietary Folate) | Calcium: 500 mg | Vit D: 600 IU | Magnesium: 206 mg | B-complex & more

Trimacare® 3

3rd Trimester
and Lactation
60
Tablets
BD
Trimacare 3

Relief from
Constipation

Bowel regulator
(Dietary fiber)

Reduces
Leg Cramps

Higher Mg + Calcium + Vit D for muscle function

Support
Postpartum recovery

Iron + Folate + B complex + Vit D + Calcium

Iron (ferrous fumarate): 27 mg | Vit C: 60 mg | Choline: 200 mg | Algal Omega 3 (EPA+DHA; 2:3): 200 mg | Vit B12: 2.45 mcg | Iodine: 200 mcg | Zinc: 12 mg | (6S)-5-MTHF: 570 mcg (Dietary Folate) | Calcium: 500 mg | Vit D: 600 IU | Higher Magnesium: 310 mg | Bowel regulator (Dietary Fiber): 125 mg | B-complex & more

Superior patient compliance

84%

of patients prefer a single pill vs
multiple pills

94%

of patients reported better tolerability
as compared to iron tablets

78%

of patients reported fewer pregnancy
symptoms like morning sickness,
constipation & fatigue

IFC

Trimacare®

IFC pills
V/s
Trimacare pill
  • Nutritional Insufficiency
  • Poor Compliance
  • Low Absorption & GI Side Effects
  • Limited Symptomatic Relief
  • Non-SpecificFormulation
  • Comprehensive Nutritional Support
  • Enhanced Compliance
  • Superior Absorption
  • Enhanced Symptomatic Relief
  • Pregnancy-Specific Formulation

What leading Ob-Gyns say about MMS

Prof. Dr. Jaideep Malhotra

MBBS, MD, FICMCH, FIAJAGO, FICOG, MASRM, FICMU, FRCOG

Founder of the Infertility Centre of Rainbow IVF

Prof. Dr. Name Here

MBBS, MD, FICOG

Founder / Consultant Obstetrician & Gynaecologist

Proud Academic Partner of ICOG Campus of FOGSI

Academic resources for the practising clinician

Get your Free Copy
ICOG Campus of FOGSI academic resource

FAQ — Answers from practising specialists.

How is Trimacare different from IFA + Calcium?

FOGSI's 2024 GCPR establishes the current Indian standard of care: iron 60–100 mg + folic acid 400 mcg daily plus calcium 1.5 g daily. This is the evidence-aligned foundation of antenatal supplementation in India. Indian pregnant women, however, present with documented simultaneous deficiencies of vitamin B12, vitamin D, iodine, zinc, choline, magnesium, and omega-3 — none of which an IFA + calcium regimen addresses.

Trimacare is a multiple micronutrient supplement (MMS) that provides over 20 nutrients in a trimester-specific, patented formulation. Cochrane systematic review (2019) and the New York Academy of Sciences expert review (2019) found that MMS reduces the risk of low birth weight, small-for-gestational-age, and stillbirth compared with IFA alone in low- and middle-income countries.

Why Quatrefolic® rather than folic acid?

Quatrefolic® is a biologically active folate form that supports folate availability without depending on the same conversion pathway required by folic acid.

Why does Trimacare include choline?

Choline supports fetal brain development, methylation pathways, and maternal nutritional needs during pregnancy.

Why ergocalciferol (D2) rather than cholecalciferol (D3)?

The formulation uses vitamin D support as part of a broader trimester-specific micronutrient profile.

What is the evidence base for MMS in pregnancy?

MMS has been studied across pregnancy outcomes including low birth weight, small-for-gestational-age births, stillbirth, and maternal nutritional status.

When should Trimacare be started, and for how long?

Trimacare is designed trimester-wise, beginning from preconception or early pregnancy and continuing through pregnancy as advised by the healthcare professional.

Rx Trimacare®
from the first antenatal visit

Improved Birth Outcomes.
Superior Patient Compliance.

Trimacare products

Available at leading pharmacies across India & online

Request your free sample